Automatic detection of CVD and osteoporosis in lung cancer screening trials

CT based screening of heavy smokers is designed for early detection of lung cancer, but also offers the possibility to detect multiple other diseases at an early stage. This is especially interesting when the screening images would allow automatic detection of these diseases.

This project is focusing on the automatic detection of cardiovascular disease and osteoporosis in lung cancer screening trials. The detection needs to be robust against various acquisition protocols, to allow application of these automatic algorithms to scans acquired in different lung cancer screening trials.

This is a collaborative project between the Image Sciences Institute (ISI), UMC Utrecht and the Diagnostic Image Analysis Group (DIAG), Radboud University Medical Center.


A section from a CT scan acquired in Dutch-Belgian lung cancer screening trial (NELSON). The image offers the possibility to quantify calcifications in the coronary arteries and in the aorta as signs of cardiovascular disease, as well as analysis of vertebra to detect  early signs of osteoporosis.



Vertebra segmentation in low-dose chest CT using an iterative fully convolutional neural network. The segmentations are used to detect vertebral compression fractures.

 

 


Researchers


Journal Articles

1.

C.C. van 't Klooster, H.M. Nathoe, J .Hjortnaes, M.L. Bots, I. Išgum, N. Lessmann, Y. van der Graaf, T. Leiner, F.L.J. Visseren, On behalf of the UCC-SMART-study group

Multifocal cardiovascular calcification in patients with established cardiovascular disease; prevalence, risk factors, and relation with recurrent cardiovascular disease Journal Article

International Journal of Cardiology, Heart & Vasculature, 27 (100499), 2020.

Abstract | Links | BibTeX

2.

N. Lessmann, B. van Ginneken, P.A. de Jong, I. Išgum

Iterative fully convolutional neural networks for automatic vertebra segmentation and identification Journal Article

Medical Image Analysis, 53 , pp. 142-155, 2019.

Abstract | Links | BibTeX

3.

N. Lessmann, P.A. de Jong, C. Celeng, R.A.P. Takx, M.A. Viergever, B. van Ginneken, I. Išgum

Sex differences in coronary artery and thoracic aorta calcification and their association with cardiovascular mortality in heavy smokers Journal Article

JACC: Cardiovascular Imaging, 12 (9), pp. 1808-1817, 2019.

Abstract | Links | BibTeX

4.

N. Lessmann, B. van Ginneken, M. Zreik, P.A. de Jong, B.D. de Vos, M.A. Viergever, I. Išgum

Automatic calcium scoring in low-dose chest CT using deep neural networks with dilated convolutions Journal Article

IEEE Transactions on Medical Imaging, 37 (2), pp. 615-625, 2018.

Abstract | Links | BibTeX

Inproceedings

1.

N. Lessmann, B. van Ginneken, P.A. de Jong, I. Išgum

Iterative fully convolutional neural networks for automatic vertebra segmentation Inproceedings

In: Medical Imaging with Deep Learning (MIDL 2018), 2018.

Abstract | Links | BibTeX

2.

N. Lessmann, B. van Ginneken, I. Išgum

Iterative convolutional neural networks for automatic vertebra identification and segmentation in CT images Inproceedings

In: SPIE Medical Imaging, pp. 1057408, 2018.

Abstract | Links | BibTeX

3.

N. Lessmann, I. Isgum, A.A.A. Setio, B.D. de Vos, F. Ciompi, P.A. de Jong, M. Oudkerk, W.P.Th.M. Mali, M.A. Viergever, B. van Ginneken

Deep convolutional neural networks for automatic coronary calcium scoring in a screening study with low-dose chest CT Inproceedings

In: SPIE Medical Imaging, pp. 978511, 2016, (Bla).

Abstract | Links | BibTeX

Abstracts

1.

A. Schreuder; C. Jacobs; N. Lessmann; E.T. Scholten; I. Išgum; M. Prokop; C.M. Schaefer-Prokop; B. van Ginneken

Improved lung cancer and mortality prediction accuracy using survival models based on semi-automatic CT image measurements Abstract

In: 2018.

BibTeX

2.

N. Lessmann, B. van Ginneken, P.A. de Jong, W.B. Veldhuis, M.A. Viergever, I. Isgum

Deep learning analysis for automatic calcium scoring in routine chest CT Abstract

In: 2017.

Abstract | BibTeX

3.

N. Lessmann, I. Isgum, S. Lam, J. Mayo, P.A. de Jong, M.A. Viergever, B. van Ginneken

Automatic coronary calcium scoring and cardiovascular risk estimation in the Pan-Canadian lung cancer screening trial Abstract

In: 2015.

Abstract | BibTeX

PhD Theses

1.

N. Lessmann

Machine learning based quantification of extrapulmonary diseases in chest CT PhD Thesis

Utrecht University, The Netherlands, 2019, ISBN: 978-94-6323-607-2.

BibTeX